[AOBIOUS 공식대리점 관련 업무대행/수입] Enzyme Inhibitors

[AOBIOUS 공식대리점 관련 업무대행/수입] Enzyme Inhibitors

[9-ING-41 (Elraglusib)]

Product Information:

• Novel glycogen synthase kinase-3 (GSK-3) inhibitor
• Cat No: AOB33534
• CAS No: 1034895-42-5
• Chemical Name: 3-​(5-​Fluorobenzofuran-​3-​yl)​-​4-​(5-​methyl-​5H-​[1,​3]​dioxolo[4,​5-​f]​indol-​7-​yl)​pyrrole-​2,​5-​dione

Data sheet:

• Molecular Formula: C22H13FN2O5
• Molecular Weight: 404.35
• Storage Condition: 0°C (short term), -20°C (long term), desiccated
• Solubility: DMSO
• Purity: 98% by HPLC
• Synonym: 9-ING-41; 9 ING 41; 9ING41; Elraglusib
• IUPAC/Chemical Name: 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione
• InChl Key: FARXPFGGGGLENU-UHFFFAOYSA-N
• InChl Code: InChI=1S/C22H13FN2O5/c1-25-7-13(11-5-17-18(6-15(11)25)30-9-29-17)19-20(22(27)24-21(19)26)14-8-28-16-3-2-10(23)4-12(14)16/h2-8H,9H2,1H3,(H,24,26,27)
• SMILESCode: CN(C1=C2C=C3C(OCO3)=C1)C=C2C4=C(C5=COC6=C5C=C(F)C=C6)C(NC4=O)=O

References:

1) Karmali R, et. GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents. Oncotarget. 2017 Nov 11;8(70):114924-114934.

2) Ugolkov A, et. Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models. Transl Oncol. 2017 Aug;10(4):669-678.

3) Pal K, Cao Y, Gaisina IN, Bhattacharya S, Dutta SK, Wang E, Gunosewoyo H, Kozikowski AP, Billadeau DD, Mukhopadhyay D. Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer. Mol Cancer Ther. 2014 Feb;13(2):285-96.
 

[AT-56]

Product Information:

• Orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS)
• Cat No: AOB1707
• CAS No: 162640-98-4
• Chemical Name: AT56; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine

Data sheet:

• Molecular Formula: C25H27N5
• Molecular Weight: 397.52
• Storage Condition: 0°C (short term), -20°C (long term), desiccated
• Solubility: DMSO
• Purity: 98% (HPLC)

[J-113863]

Product Information:

• Potent and selective inhibitor of CCR1 and CCR3
• Cat No: AOB9218
• CAS No: 353791-85-2

Data sheet:

• Molecular Formula: C30H37Cl2IN2O2
• Molecular Weight: 655.44
• Storage Condition: 0°C (short term), -20°C (long term), desiccated
• Solubility: 60 mg /mL in DMSO and 33 mg/mL in EtOH
• Purity: 98% (HPLC)
• Synonym: J113863; UCB-35625
• IUPAC/Chemical Name: 1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
• InChl Key: FOAFBMYSXIGAOX-LQGGPMKRSA-N

References:

1) Naya et al (2001) Design, synthesis, and discovery of a novel CCR1 antagonist. J.Med.Chem. 44 1429 PMID: 11311066

2) Amat et al (2006) Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br.J.Pharmacol. 149 666 PMID: 17016504

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